Luis Marquez, 33, receives a coronavirus disease vaccination at a mobile vaccination drive for essential food processing workers at Rose & Shore in Vernon, Los Angeles, California, US, on March 17, 2021.
Five of the 10 variants were "highly resistant to neutralisation" even when volunteers had received both doses of the vaccines, the researcherson Friday in Cell. All five highly resistant variants had mutations in the spike on the virus surface, known as K417N/T, E484K, and N501Y, that characterise a variant rampant in South Africa and two variants spreading rapidly in Brazil.
"While studies of the New York variant are ongoing, our findings suggest that similar variants harbouring E484K may be harder for vaccine-induced antibodies to neutralize," said study leader Alejandro Balazs of Harvard University and the Massachusetts General Hospital. For every three people who died within four weeks after being infected with another variant, roughly five died after becoming infected with B.1.1.7, according to a paperOverall, the risk of death with B.1.1.7 was 67 percent higher than the risk with other variants in England, the authors said.
The ability of the variant to cause severe disease, or its pathogenicity, is still unclear. "The P.1 variant has already been detected in at least 25 countries," the authors said. "This calls for urgent ... studies of the P.1 variant, since greater transmissibility and pathogenicity can drive even well-prepared health systems to collapse.
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