Covid-19 science round-up: Miniature organs help test treatments

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Can tiny organ-like structures grown in labs help screen drugs and does diarrhoea point to more severe Covid-19 infections? The latest science looking at the virus 👇

A scientist works in a laboratory where a vaccine against the Covid-19 is being produced at the Oxford Vaccine Group's facility at the Churchill Hospital in Oxford, Britain, June 24, 2020.

Their team developed organoids containing types of lung and colon cells that are known to become infected in people with Covid-19. In collaboration with teams at Columbia University and Icahn School of Medicine at Mount Sinai, they screened 1,200 FDA-approved drugs and found three that showed activity against the novel coronavirus, including the cancer drug imatinib, sold as Gleevec by Novartis. It is currently being tested in four different Covid-19 clinical trials.

He said doctors evaluating Covid-19 patients need to bear in mind that GI symptoms may signal a markedly higher risk of a worsened disease course. Both studies were presented at the American College of Gastroenterology virtual annual meeting. A new wave of coronavirus infections has been spreading in the UK, but the proportion of the population there with antibodies to the virus has been shrinking, new data show.

Antibodies are not the body's only line of defence. Also important are immune cells called T cells and B cells that stimulate antibody production.

 

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