Colombian family's genes offer new clue to delaying onset of Alzheimer's

In this undated photo provided by Massachusetts General Hospital, Dr. Francisco Lopera, right, of the University of Antioquia, a neurologist who has spent decades caring for a large Colombia n family plagued by early-in-life Alzheimer’s, confers with fellow researcher Yakeel Quiroz of Massachusetts General Hospital.

The first hint of this genetic protection came a few years ago. Researchers were studying a huge family in Colombia that shares a devastating inherited form of Alzheimer’s when they discovered one woman who escaped her genetic fate. Aliria Piedrahita de Villegas should have developed Alzheimer’s symptoms in her 40s but instead made it to her 70s before suffering even mild cognitive trouble.

The findings, published in the New England Journal of Medicine, are encouraging, said Dr. Eliezer Masliah of the National Institute on Aging.

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