Scientists have used a cannabis-based drug to reduce seizures in children with a rare form of epilepsy, according to a new study.
Study co-author Dr. Ian Miller of Miami's Nicklaus Children's Hospital told Newsweek this new study shows that a lower dose of 10 milligrams per kilogram of body weight, taken daily, is as effective as the 20 mg/kg per day dose researched in a 2017 paper. It is therefore the second randomized, double-blind clinical trial showing that Epidiolex is effective at treating seizures associated with Dravet syndrome.
However, the drug caused side effects, such as poor appetite, diarrhea, fatigue and fever, causing a total of 7 percent of the children in the high-dose group to stop their treatment. Around a quarter of the children in the high-dose group experienced what were described as serious side effects. This dropped to a fifth among the low-dose group and 15 percent among those using a placebo.
Miller said the study was limited, however, because its focus was on a specific type of epilepsy and type of cannabidiol: the highly purified, plant-derived pharmaceutical formulation of cannabidiol called Epidiolex."Further studies are needed to scientifically demonstrate how other forms of epilepsy or other forms of cannabidiol or cannabis affect seizures," he said.
Miller said in a statement:"It's exciting to be able to offer another alternative for children with this debilitating form of epilepsy and their families." He went on to caution that upping doses to above 10 mg/kg per day"should be carefully considered based on the effectiveness and safety for each individual."
Source: Law Daily Report (lawdailyreport.net)
RT : Child seizures reduced with cannabis-based epilepsy drug in clinical trial
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