CDH1 Linked With New Hereditary Breast Cancer Syndrome

identify a form of hereditary lobular BC that is unrelated to the better-known breast-ovarian syndrome linked to alterations invariants are associated with risk for diffuse gastric cancer and lobular breast cancer in the so-called hereditary diffuse gastric cancer syndrome.

In the setting of the HLBC phenotype,"the overall frequency is not well established due to a lack of large, prospective cohort studies," wrote the investigators. They analyzed women with LBC who met HLBC clinical criteria to evaluate the frequency of germline variants indates back a long time.

These findings provided the idea of the project, which was funded by the Italian Ministry of Health in 2016. The results were published recently. The study involved a single-center cohort of just under 5500 primary lobular breast tumors, of which 34.4% presented the hereditary phenotype. Tests for germline variants of"These women were selected based on specific criteria such as age < 45 years, a positive family history of breast cancer, or bilateral lobular cancer manifestation," said Corso. No germline variants ofvariants were pathogenic or probably pathogenic.

How do these results affect clinical practice?"Currently, we mainly rely on the clinical characteristics of the disease to decide whether to perform the test for identifyingtest," said Corso."We hope that our results will provide a push to establish the possibility of performing the test following the criteria that emerged from the analysis: Very young women , those with bilateral lobular cancer manifestation, or even simply those with a positive family history of breast cancer.

Source: Healthcare Press (healthcarepress.net)

Malignant Breast Neoplasm Breast Carcinoma Noncolorectal Gastrointestinal Cancer Noncolorectal Gi Cancer Family Hx Of Malignant Breast Neoplasm Family History Of Breast Cancer Hx Of Malignant Breast Neoplasm History Of Breast Cancer Genetic Testing Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Gastric Cancer Malignant Stomach Neoplasm Stomach Cancer

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