White House chief medical advisor Dr. Anthony Fauci to step down in December after more than 50 years of public service
Officials at the FDA and CDC have said the omicron BA.1 and omicron BA.5 boosters are similar enough that the immune response data from the BA.1 shot should give a good indication of how the BA.5 shots will perform. Omicron BA.1 and BA.5 are closely related with a four-mutation difference, according to Dr. Jacqueline Miller, who works on vaccine development at Moderna.
Oliver, the CDC official, told the committee that health officials do not expect any difference in the safety profile of the BA.1 and BA.5 shots given that subvariants differ only by a few mutations. Infections, hospitalizations and deaths have declined dramatically since the massive wave of omicron infection last winter, but have plateaued this summer at a stubbornly high level. Omicron BA.5 is the most contagious and immune evasive variant yet, and breakthrough infections have become increasingly common as a consequence.
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