Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses

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Preclinical experiments in human cells and mice suggest CBD may prevent the replication of SARSCoV2, but the authors advise caution until completion of a clinical trial, citing questions on dosage, formulation, and mode of delivery. ScienceAdvances

). The project described was supported by the National Institute of General Medical Sciences, 5U54GM104942-04. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. The analysis used only de-identified data . We gratefully acknowledge contributions from the following N3C core teams:Workstream, subgroup and administrative leaders

: Melissa A. Haendel, Tellen D. Bennett, Christopher G. Chute, David A. Eichmann, Justin Guinney, Warren A. Kibbe, Hongfang Liu, Philip R.O. Payne, Emily R. Pfaff, Peter N. Robinson, Joel H. Saltz, Heidi Spratt, Justin Starren, Christine Suver, Adam B. Wilcox, Andrew E. Williams, Chunlei WuIndividuals at the sites who are responsible for creating the datasets and submitting data to N3C: Christopher G. Chute, Emily R. Pfaff, Davera Gabriel, Stephanie S. Hong, Kristin Kostka, Harold P.

• Publication Committee Management Team: Mary Morrison Saltz, Christine Suver, Christopher G. Chute, Melissa A. Haendel, Julie A. McMurry, Andréa M. Volz, Anita Walden: Carolyn Bramante, Jeremy Richard Harper, Wenndy Hernandez, Farrukh M Koraishy, Federico Mariona, Saidulu Mattapally, Amit Saha, Satyanarayana Vedula.

 

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ScienceAdvances The cell culture effective doses were in the uM range - that’s not useful. It needs to be in the nM range. The bioavailability (COVID infected cells) and metabolism/elimination kinetics are all negatives for this kind of product. The needed cellular dose is hard to achieve.

ScienceAdvances Hi, I am a structural engineer from Iran who have many ideas. I have summarized some of my ideas on my twitter(I suggest look at the idea of generating electricity by gravity). I want to work with companies and investors. Do you want to cooperate?

ScienceAdvances Interesting stuff 🤔

ScienceAdvances May pharma not going to be a get gate keeper

ScienceAdvances concept as a bronchial dialator response specific to the interaction given by CBD...it makes sense to follow the line of reason to the familys of fir needle as a compound..Fir Temporal range: Eocene - Present Family:Pinaceae Subfamily:Abietoideae Genus:Abies Mill. Type species

ScienceAdvances so the bxo1 inhibits that rna molecule of that cbd compost, wow amazing. i dont know what i justsaid.

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