CAH Treatment 'Struggle' Points to Unmet Need

NEW ORLEANS — Children and adults with congenital adrenal hyperplasia often receive supraphysiologic doses of glucocorticoids, resulting in adverse effects while at the same time not achieving adequate androgen suppression.

Session Moderator Anupam Kotwal, MD, assistant professor in the Division of Diabetes, Endocrinology and Metabolism, at the University of Nebraska Medical Center, Omaha, Nebraska, told,"We struggle a lot with trying to get patients better controlled from their androgen standpoint in CAH but then not give them all the side effects from too much glucocorticoid."

Consequently,"Participants experienced a spectrum of disease-related and treatment-related comorbidities. Participants showed clinical evidence of GC, ACTH, and androgen excess, including high prevalence of obesity, hirsutism in females, and testicular adrenal rest tumors in males," Hamadi said.

Source: Healthcare Press (healthcarepress.net)

Obese Glucocorticosteroids Glucocorticoid Therapy Glucocorticoid Children Child Childhood Pediatrics Kids Patient Safety Congenital Adrenal Hyperplasia Adverse Effects Side Effects Washington DC Washington - District Of Columbia Endocrine Society Endocrinology Endocrine System Nebraska Washington CV Risk Cardiovascular Risk CV Risk Factors Cardiovascular Risk Factors

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