Brains of The Living And The Dead Don't Read Key Genes in The Same Way

Death, to put it mildly, is a rather inconvenient event for a living brain. The cascade of effects that arises as oxygen vanishes sweeps like a tide down to the very way our cells transcribe and translate our DNA, scrambling in a

Researchers from the Icahn School of Medicine at Mount Sinai in New York focused on the way specific base codes of adenosine are swapped for a completely different base, inosine , in messenger RNA."By using fresh samples from living individuals, we were able to uncover significant differences in RNA editing activity that previous studies, relying only on postmortem samples, may have overlooked.

Billions of years of evolution has taken advantage of this intermediary transcription and translation service to virtually add in a whole new library of proteins. Like a rogue editor rewording manuscripts to serve entirely new purposes, cells can tweak a gene's messenger RNA to meet entirely different needs.

The team's analysis distinguished in excess of 72,000 locations on RNA strands where A-to-I editing occurred more often in specimens from the recently deceased, compared with those collected from a living patient.

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