Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron - Nature

. While recent reports reveal that the Omicron variant robustly escapes from vaccine and therapeutic neutralization antibodies, the pathogenicity of the virus remains unknown. Here we show that the replication of the Omicron variant is dramatically attenuated in Calu3 and Caco2 cells.

Huiping Shuai, Jasper Fuk-Woo Chan, Bingjie Hu, Yue Chai, Terrence Tsz-Tai Yuen, Xiner Huang, Chaemin Yoon, Huan Liu, Jialu Shi, Yuanchen Liu, Tianrenzheng Zhu, Jinjin Zhang, Yuxin Hou, Yixin Wang, Lu Lu, Jian-Piao Cai, Anna Jinxia Zhang, Jie Zhou, Shuofeng Yuan, Kelvin Kai-Wang To, Kwok-Yung Yuen & Hin Chu

Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, Hainan, ChinaAcademician Workstation of Hainan Province, Hainan Medical University, Haikou, Hainan, People’s Republic of ChinaHainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, The University of Hong Kong; Pokfulam, Hong Kong Special Administrative Region, Hong Kong, ChinaCAS Key Laboratory of Quantitative Engineering Biology,...

Well, this is sorta consistent with the hypothesis, floated by some, that Omicron jumped back into human population from mice through 360° zoonosis. Unfortunately mouse data are not very predictive when applied to humans.

Interesting...

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