ART Safe for Breast Cancer Survivors With BRCA1/2 Mutations

"Our primary aim was to evaluate the safety profile of ART in this high-risk population by comparing maternal and fetal outcomes between those who conceived spontaneously versus those using ART," explained Matteo Lambertini, MD, PhD, during his talk at the conference."We found no statistically significant differences in pregnancy complications or fetal abnormalities.

Dr Janice Tsang, MD, a clinical oncology specialist and assistant professor at the University of Hong Kong who was not involved in this study, highlighted that this is the largest study focusing on ART safety in young patients withmutation carriers studied across nearly 80 sites, the cohort analysis had sufficient statistical power and global representation to detect potential safety signals with ART utilization, unlike prior smaller studies," she said.

rates and lower rates of induced abortion than women with spontaneous conceptions, the analysis revealed no statistically significant differences in the frequency of pregnancy complications, delivery complications, or congenital abnormalities between those who received ART and those who conceived naturally.

Dr Lambertini explained that variations in baseline characteristics, such as age, may have contributed to differences in miscarriage rates. "Patients in the ART group tended to be older at the time of conception, with a median age of 37.1 years, compared with 34.3 years in the spontaneous pregnancy group," he said, during his presentation. Women in the ART group also more frequently had hormone receptor-positive breast cancer and longer median time from diagnosis to conception .At a median follow-up of 5.

Source: Entertainment Trends (entertainmenttrends.net)

Malignant Breast Neoplasm Breast Carcinoma Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Cancer Survivor Breast Mammary Gland Ovarian Cancer Malignant Ovarian Neoplasm Ovary Cancer Pregnancy Pregnant Fertility Prognosis Spontaneous Abortion Miscarriage

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