Arenaviral infection causes bleeding in mice due to reduced serotonin release from platelets

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New experiments in mice in SciSignal clarify how infections with an arenavirus can cause dangerous bleeding, and hint that platelet transfusions could help stanch hemorrhage in infected patients. InfectiousDisease

We thank D. Pinschewer, M. Cattaneo, G. Poli, and P. Dellabona for the helpful discussions; P. M. Mainetti, M. Raso, I. Fermo, A. Fiocchi, and D. Covarello for technical assistance; M. Panzeri for TEM; Zordan, A. Monestiroli, and E. Daoud for qPCR experiments; and J. Koziol for statistical revision. We would like to acknowledge the PhD program in Basic and Applied Immunology at San Raffaele University because R.A.

was supported by a fellowship of MERU Foundation, Italy, at the MERU-Roon Research Center for Vascular Biology of the Scripps Research Institute.R.A., G.S., M.I., L.G.G., and Z.M.R. designed the study; R.A., G.S., M.I., and I.B. performed the experiments and collected data; R.A., G.S., M.I., I.B., and Z.M.R. analyzed the data; and R.A. and Z.M.R. wrote the manuscript with critical comments by G.S., M.I., and L.G.G.Z.M.R. is founder, president, and CEO of MERU VasImmune Inc.

 

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