in the adjuvant setting following tumor resection in patients with anaplastic lymphoma kinase –positive non–small cell lung cancer , as detected by an FDA-approved test.
The kinase inhibitor was previously approved as first- and second-line treatment for ALK-positive metastatic NSCLC. Patients had resectable stage IB to IIIA tumors with ALK rearrangements identified by a locally performed FDA-approved ALK test or by a centrally performed Ventana ALK CDx assay. The most common adverse reactions with alectinib, occurring in 20% or more patients, were hepatotoxicity, constipation, myalgia, COVID-19, fatigue, rash, and cough.
Lung Carcinoma Cancer Of The Lung Non-Small Cell Lung Cancer Nsclc Anaplastic Lymphoma Kinase ALK ALK Tyrosine Kinase Receptor CD246 Cluster Of Differentiation 246 Anaplastic Lymphoma Kinase Inhibitor ALK Inhibitor Otolaryngology ENT Specialty Head And Neck Surgery ENT Speciality Tumor Chemotherapy Toxicology Toxicity Poisoning Toxins Small Cell Lung Cancer
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