Across the same set of 478 tumours, we compared the SNP6-array based copy number profiles and signatures to copy number profiles and signatures derived using different copy number profiling technologies. The columns contain results for the different technologies and the rows contain results for comparison between copy number profiles , signature activities and signature definitions . For each comparison we show results for a range of penalties for ASCAT’s piecewise constant fitting or ASCAT.
Boxes with a red line indicate significant associations that were not considered when determining signature aetiologies as the significant enrichment was via amplification of the gene, which also resided in an ecDNA amplicon, which could be a consequence of the signature rather than a cause, potentially causing a spurious correlation with amplification signatures ., Each row shows highly significant associations between signatures and different covariates.
Source: Healthcare Press (healthcarepress.net)
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