collect and analyse RNA molecules circulating freely in the bloodstream — known as cell-free RNA — from more than 1,800 pregnant individuals of various ages, body mass indices and races, from different continents and at different stages of their pregnancies.
The analyses provide insight into normal fetal, placental and maternal changes in gene expression across gestation. The authors then use this knowledge of normal cfRNA signatures in pregnancy to predict the development of a potentially dangerous pregnancy complication called pre-eclampsia.
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