Zika virus-specific synthetic molecule can differentiate between prior infections with different flaviviruses

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Antibodies,Antibody,Blood

A newly discovered Zika virus-specific synthetic molecule is capable of differentiating Zika-immune patient samples from samples of patients previously infected with the related dengue virus.

May 14 2024University of Pittsburgh The technology may lead to the development of better diagnostics and vaccine candidates, scientists announced today in the Proceedings of the National Academy of Sciences.

Priscila Castanha, Ph.D., first author, assistant professor, Department of Infectious Disease and Microbiology, Pitt Public Health If any of the PICCOs match the corresponding shape of an antibody in the blood sample, the antibody will hook onto them and researchers can "fish" it out. The presence of an antibody against a virus in someone's blood means that they were previously infected with or vaccinated against that virus, prompting their immune system to produce antibodies.

Related StoriesCastanha, Burke and co-senior author Ernesto T.A. Marques, M.D., Ph.D., associate professor in Pitt Public Health's Department of Infectious Disease and Microbiology, have been studying Zika virus since it emerged in the Americas in 2015. Prior to its emergence in Brazil, Castanha, Marques and Burke were studying dengue virus.

Antibodies Antibody Blood Diagnostic Diagnostics Immunity Microbiology Molecule Mosquito Pathogen Ph Pregnancy Public Health Research Vaccine Virus Zika Virus

 

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