What is the efficacy of COVID-19 BNT162b2 and mRNA-1273 booster vaccinations?

By Shanet Susan AlexAug 2 2022Reviewed by Aimee Molineux In a recent study posted to the medRxiv* preprint server, scientists compared the effectiveness of the severe acute respiratory syndrome coronavirus 2 BNT162b2 and mRNA-1273 vaccine booster doses in England.

About the study In the current study, on account of National Health Service England, the researchers used the OpenSAFELY-TPP database to match adults who received the SARS-CoV-2 mRNA-1273 or BNT162b2 vaccine on vaccination date, age, primary vaccine course, and other factors.

Results Overall, the study results showed that during the research period, 10,139,268 people registered at a TPP practice had a COVID-19 booster shot with either mRNA-1273 or BNT162b2 , with 6,264,525, i.e., 86.5%, and 6,264,525, i.e., 87.1%, eligible for matching. Compared to mRNA-1273 booster recipients, eligible BNT162b2 booster recipients were typically more deprived, older, and more likely to have a history of clinical conditions.

Less than one in 3,800 booster recipients were hospitalized with COVID-19, and less than one in 100,000 died with COVID-19 as a contributing or underlying cause. Severe COVID-19 disease was extremely uncommon up to 12 weeks post-booster vaccination. Regardless of clinical vulnerability, age, or evidence of past infection, the relative efficacy of mRNA1273 versus BNT162b2 against COVID-19 hospitalization was comparable.

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