What is the effect of COVID-19 vaccination in pregnant and postpartum women infected with different SARS-CoV-2 variants?

By Dr. Liji Thomas, MDOct 12 2022Reviewed by Benedette Cuffari, M.Sc. The coronavirus disease 2019 generally affects women less severely than men, with a significant exception during pregnancy, which is considered a high-risk factor for more severe illness.

The emergence of several SARS-CoV-2 variants affected its trajectory. Among these, some were not significantly different from the ancestral strain in their biological or epidemiological characteristics. The researchers used a national Brazilian database called the System of Information about Epidemiological Surveillance of Influenza . To this end, they searched between December 29, 2019, and July 16, 2022, for obstetric COVID-19 patients who required hospitalization.

Related StoriesIn comparison, Gamma infection in the same group was associated with 1.5-fold and two-fold higher odds for ICU admission and requiring invasive ventilation or die, respectively, as compared with pregnant unvaccinated women. With vaccination, the likelihood of death was still 2.5-fold higher among puerperal women.

The researchers propose a “three delays model” to explain the increased risk of severe COVID-19 among this patient population. This model suggests that puerperal women ignore their own health because of their focus on their babies.

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