By Bhavana KunkalikarJan 11 2023Reviewed by Aimee Molineux In a recent study published in the JAMA Network Open journal, researchers evaluated the relationship between congenital cytomegalovirus infection and acute lymphoblastic leukemia .
About the study In the present study, researchers determined the predominance of cCMV infection among ALL patients and matched controls. For efficient adjustment of confounding, the sex, race, and ethnicity of the mother were matched, whereas the birth year was matched to have equal windows of exposure. The birth registry was linked to data on birth characteristics, the mother's ethnicity and race, and previously established risk factors. CMV deoxyribonucleic acid detection in DBS was performed, followed by quantitative multiplex polymerase chain reaction .
The average pregnancy weight increase was comparable across mothers of both cases as well as controls. According to birth certificates, there were no considerable differences in mothers' smoking and alcohol consumption during pregnancy. The prevalence of pre-pregnancy or gestational diabetes was somewhat greater among mothers of cases, although this difference was not statistically significant.
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