By Neha MathurSep 27 2022Reviewed by Danielle Ellis, B.Sc. In a recent study posted to the medRxiv* server, researchers investigated cognitive deficits associated with acute severe acute respiratory syndrome coronavirus 2 infection.
Those 11 participants with Long-COVID had persistent symptoms after 16 weeks of initial infection. A clinician with expertise in investigating Long-COVID interviewed these participants and ensured the status of the initial SARS-CoV-2 infection. Further, they ensured that none of the participants had any substance use disorder or were regular alcohol, marijuana, and nicotine users in the past 90 days. They used urine drug screens to screen these substances on the day of testing.
For multiple regression analysis, the team used each demographics, such as age, gender, and education, as fixed effects. The study outcomes comprised the Neuro-Quality of Life questions reports and cognitive and sensorimotor measures. Finally, the researchers used Hotelling's two-sample T2-multivariate test to examine the differences in the Neuro-QoL response profiles of all participants.
The degree of impairment across different neuropsychological domains also varied among the participants of the three study groups. The d2 Test of Attention results provides evidence of impairments in sustained attention, selective attention, and processing speed in the COVID-19 group. Likewise, the Eriksen Flanker Task also evidenced attentional dysfunction related to SARS-CoV-2 infection.
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