By Bhavana KunkalikarJul 28 2022Reviewed by Aimee Molineux In a recent study posted to the bioRxiv* preprint server, researchers assessed the antibody response and cellular immunity induced by severe acute respiratory syndrome coronavirus 2 Omicron infection in children.
The team assessed the neutralizing ability of sera obtained from individuals who reported a natural infection with SARS-CoV-2 variants, which were predominant before Omicron. Antibody binding ability to the SARS-CoV-2 wild-type and Omicron spike and receptor-binding domain regions was estimated in serological samples collected from 54 children aged between five and 15, infected with a pre-Omicron variant.
Results The study results showed that the relative antibody binding activity to the SARS-CoV-2 Omicron S and RBD declined remarkably in children as well as adults in comparison to that of the wild-type strain. The relative binding decreased by 85% in children and 88% in adults, while only 41% exhibited a positive RBD response. This indicated that recognition of Omicron by the antibodies in sera after a pre-Omicron infection was noticeably lowered in children and adults.
Furthermore, weak neutralization activity was elicited by primary Omicron infection while only 53% of the infected children displayed detectable neutralization titers despite a previous infection. On the other hand, robust neutralization was noted after secondary infection with measurable neutralization titers.
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