"However, Lois' own work-life balance is put to the test when an undercover assignment reveals a deadly foe that promises to change the Kent family forever," the synopsis continues."Superman would move heaven and earth for his family, but with a villain this merciless, even that might not be enough.
"Meanwhile, the Kent boys find themselves being pulled in opposite directions as Jordan discovers what a superhero identity really means and Jonathan searches for purpose beyond the football field."BBC iPlayer in the UK.
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Walking pace, handgrip strength, age, APOE genotypes, and new-onset dementia: the UK Biobank prospective cohort study - Alzheimer's Research & TherapyBackground The independent and additive associations of walking pace and grip strength on dementia risk and the potential modifying effects of age, APOE phenotypes, and other dementia risk factors on the walking pace and dementia relationships demand further clarification. We aimed to investigate the independent and additive relationships of walking pace and handgrip strength on the risk of new-onset dementia and examine the potentially modifying effects of age, APOE phenotypes, lifestyle factors, and family history of dementia in the relationships. Methods A total of 495,700 participants from the UK Biobank, who were free of dementia at baseline, were included in this study. Walking pace was self-defined as slow, average, or brisk. Handgrip strength was assessed by dynamometer and was divided into sex-specific quartiles. The APOE genotypes were determined by a combination variant of rs429358 and rs7412. Other dementia risk factors, including education, physical activity, hypertension, depression, diabetes, and family history of dementia, were also collected. The primary outcome was new-onset all-cause dementia. Results Over a median follow-up duration of 12.0 years, 3986 (0.8%) participants developed new-onset all-cause dementia. Compared with those with slow walking pace, participants with average (HR, 0.61; 95%CI: 0.55–0.68) or brisk (HR, 0.59; 95%CI: 0.52–0.67) walking pace had a significantly lower risk of new-onset all-cause dementia. Moreover, compared with those with both slow walking pace and lower handgrip strength (the first quartile), the lowest risk of new-onset all-cause dementia was observed in participants with both average or brisk walking pace and higher handgrip strength (the 2–4 quartiles) (HR, 0.45; 95%CI: 0.40–0.52). Notably, the negative relationship between walking pace and the risk of new-onset all-cause dementia was significantly reduced as APOE ε4 dosage increased (APOE ε4 dosages = 0 or 1: brisk vs. slow: HR, 0.55; 95%CI: 0.48–0.63; vs. A
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Public bash 'stupid people' seen walking on ice across NorthantsFamilies with their young children and even pets were seen walking on frozen lakes
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Dad-to-be branded a ‘walking red flag’ after his babies gender-reveal reactionWE’VE seen our fair share of gender reveal parties over the past few years and it looks like the American trend isn’t going away any time soon. Although it seems some gender reveal parties ar…
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