How did social prescribing contribute to meeting the complex health and social needs of people at high risk of type 2 diabetes? Qualitative findings
Our study also revealed that patients often lacked confidence and felt guilty or helpless to reach out and access the services they required. As expressed by a patient referred into SP: “I know how to contact her [the link worker] but you know, […] I don’t want to feel that you know – I feel a bit guilty really that I didn’t follow up on a lot of the information that she gave me” [SPU 04.1]. Additional support was often needed to help them navigate SP.
Regular services, conversely, allowed for the provision of ongoing support. Patients could build on previous work and share the burden of critical social and health constraints: “I just felt a little bit better that I’m not dealing with this on my own” [SPU 04.3]. Continuity of care allowed providers to monitor patients’ progress and adapt their approach and next steps accordingly.
Source: Healthcare Press (healthcarepress.net)
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Identification of biomarkers related to copper metabolism in patients with pulmonary arterial hypertension - BMC Pulmonary MedicineBackground The pathogenesis of pulmonary arterial hypertension (PAH) and associated biomarkers remain to be studied. Copper metabolism is an emerging metabolic research direction in many diseases, but its role in PAH is still unclear. Methods PAH-related datasets were downloaded from the Gene Expression Omnibus database, and 2067 copper metabolism-related genes (CMGs) were obtained from the GeneCards database. Differential expression analysis and the Venn algorithm were used to acquire the differentially expressed CMGs (DE-CMGs). DE-CMGs were then used for the coexpression network construction to screen candidate key genes associated with PAH. Furthermore, the predictive performance of the model was verified by receiver operating characteristic (ROC) analysis, and genes with area under the curve (AUC) values greater than 0.8 were selected as diagnostic genes. Then support vector machine, least absolute shrinkage and selection operator regression, and Venn diagrams were applied to detect biomarkers. Moreover, gene set enrichment analysis was performed to explore the function of the biomarkers, and immune-related analyses were utilized to study the infiltration of immune cells. The drug-gene interaction database was used to predict potential therapeutic drugs for PAH using the biomarkers. Biomarkers expression in clinical samples was verified by real-time quantitative PCR. Results Four biomarkers (DDIT3, NFKBIA, OSM, and PTGER4) were screened. The ROC analysis showed that the 4 biomarkers performed well (AUCs | 0.7). The high expression groups for the 4 biomarkers were enriched in protein activity-related pathways including protein export, spliceosome and proteasome. Furthermore, 8 immune cell types were significantly different between the two groups, including naive B cells, memory B cells, and resting memory CD4 T cells. Afterward, a gene-drug network was constructed. This network illustrated that STREPTOZOCIN, IBUPROFEN, and CELECOXIB were shared by the PTGER4 and
Source: BioMedCentral - 🏆 22. / 71 Read more »
Water intake, hydration status and 2-year changes in cognitive performance: a prospective cohort study - BMC MedicineBackground Water intake and hydration status have been suggested to impact cognition; however, longitudinal evidence is limited and often inconsistent. This study aimed to longitudinally assess the association between hydration status and water intake based on current recommendations, with changes in cognition in an older Spanish population at high cardiovascular disease risk. Methods A prospective analysis was conducted of a cohort of 1957 adults (aged 55–75) with overweight/obesity (BMI between ≥ 27 and | 40 kg/m2) and metabolic syndrome from the PREDIMED-Plus study. Participants had completed bloodwork and validated, semiquantitative beverage and food frequency questionnaires at baseline, as well as an extensive neuropsychological battery of 8 validated tests at baseline and 2 years of follow-up. Hydration status was determined by serum osmolarity calculation and categorized as | 295 mmol/L (hydrated), 295–299.9 mmol/L (impending dehydration), and ≥ 300 mmol/L (dehydrated). Water intake was assessed as total drinking water intake and total water intake from food and beverages and according to EFSA recommendations. Global cognitive function was determined as a composite z-score summarizing individual participant results from all neuropsychological tests. Multivariable linear regression models were fitted to assess the associations between baseline hydration status and fluid intake, continuously and categorically, with 2-year changes in cognitive performance. Results The mean baseline daily total water intake was 2871 ± 676 mL/day (2889 ± 677 mL/day in men; 2854 ± 674 mL/day in women), and 80.2% of participants met the ESFA reference values for an adequate intake. Serum osmolarity (mean 298 ± 24 mmol/L, range 263 to 347 mmol/L) indicated that 56% of participants were physiologically dehydrated. Lower physiological hydration status (i.e., greater serum osmolarity) was associated with a greater decline in global cognitive function z-score over a 2-year period (β: − 0
Source: BioMedCentral - 🏆 22. / 71 Read more »
Diagnostic classification of childhood cancer using multiscale transcriptomics - Nature MedicineA new multilevel clustering approach applied retrospectively to 13,000 transcriptomes of different tumors reveals a new diagnostic classification of childhood cancers, in some cases allowing a better prediction of disease outcomes. SickKidsNews SickKidsCancer StBaldricks TIPS_SPIIE A critical review of Vitamin D and Cancer: A report of the IARC Working Group William B Grant. Dermatoendocrinol. 2009 Jan. Author William B Grant PhD wbgrant2 SickKidsNews SickKidsCancer StBaldricks TIPS_SPIIE Maybe. Or maybe this is biased because nature endorses political entities for money and has a permanent conflict with anything it now publishes, including the numerous retracted “studies” over the last few years. What a shame nothing printed here can be taken seriously anymore
Source: medical_xpress - 🏆 101. / 51 Read more »
Cancer Prevalence Among Adults with Criminal Justice Involvement from a National Survey - Journal of General Internal MedicineHow incarceration raises risk of cancer and death, even after release yale PLOSONE
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Egg consumption reduces the risk of depressive symptoms in the elderly: findings from a 6-year cohort study - BMC PsychiatryBackground Accumulating evidence showed that dietary habits might modify the risk of depression. This study aimed to evaluate the longitudinal association of egg consumption with depressive symptoms in the Chinese elderly. Methods We analyzed the data from Zhejiang Ageing and Health Cohort Study including 8289 participants. The Patient Health Questionnaire-9 scale (PHQ-9) was used to assess depressive symptoms at baseline and three waves of follow-up (2015, 2016, and 2019–2020). A PHQ-9 cut-off score ≥ 5 was used to define depressive symptoms. The participants with depressive symptoms at baseline were excluded. Egg consumption was evaluated through the diet habits section of the baseline questionnaire. Self-reported egg consumption was measured as the number of eggs per week and categorized into three categories. Log-binomial regression models with Generalized Estimating Equations were utilized to evaluate the association of egg consumption with depressive symptoms and estimate relative risks (RRs). Results The mean age of included participants was 68.6 years. After 6 years of follow-up, 1385 (16.7%) participants were indicated with depressive symptoms by PHQ-9 at least once. Compared with non-consumers or less-than-weekly consumers, participants consuming | 3 eggs/week and ≥ 3 eggs/week had 30% (RR = 0.70, 95%CI 0.62–0.80) and 38% (RR = 0.62, 95%CI 0.54–0.71) lower risks of depressive symptoms, respectively. A linear association was confirmed (P for trend | 0.01), and each egg increment per week was associated with a 4% lower risk of depressive symptoms (RR = 0.96, 95%CI 0.93–0.99). Sensitivity analyses yielded consistent results to the main analyses. Conclusions Egg consumption is prospectively related to a lower risk of depressive symptoms in the Chinese elderly. More prospective studies are needed to verify the association.
Source: BioMedCentral - 🏆 22. / 71 Read more »
Towards artificial intelligence-based learning health system for population-level mortality prediction using electrocardiograms - npj Digital Medicinenpj Digital Medicine - Towards artificial intelligence-based learning health system for population-level mortality prediction using electrocardiograms
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