UCI researchers discover gene critical for muscle repair

Nov 12 2023University of California, Irvine The key human skeletal muscle gene was also found in a subset of muscle fibers that were able to support human muscle stem cells after transplantation.

With our discovery, the development of "muscle in a dish" is one step closer to reality. We've been researching this for years, and it's implication for treating disease and muscle disorders and tears are immense." Damage to the rotator cuff muscles and tendon result in loss of mobility, prolonged hospitalization, and increased dependency on health care providers. Even after surgical attachment of the rotator cuff tendon to the bone, the muscle often fails to regenerate or incompletely regenerates, leading to decreased function.

Researchers demonstrated the formation of regenerating human myofibers following transplantation are a key source of niche emergence from transplanted human cells, which has previously been overlooked.

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