Twendee X shows promise in reducing oxidative stress in systemic sclerosis

May 17 2024Louis Pasteur Center for Medical Research Autoimmune diseases occur when the body's immune system attacks healthy cells instead of protecting them. Systemic sclerosis is one such autoimmune condition characterized by faulty circulatory and immune systems, leading to the occurrence of fibrosis of the skin and internal organs. SSc is known to affect patients throughout their lives, thereby, impairing their quality of life.

To this end, a team of researchers from Japan, led by Professor Haruhiko Inufusa, who is the Chief Research Scientist at the Louis Pasteur Center for Medical Research, and a distinguished faculty at the Division of Anti-Oxidant Research, Life Science Research Center, Gifu University, has investigated the effectiveness of Twendee X® -;a dietary supplement comprising of a combination of eight active antioxidants-;in reducing oxidative stress in SSc mouse models.

The eight constituents of TwX include vitamin C, L-glutamine, niacin, L-cystine, coenzyme Q10, vitamin B2, succinic acid, and fumaric acid. The combined antioxidant effect is likely more potent than the activity of either compound alone. Previous studies have demonstrated improvement in cognition, memory, and motor coordination in mouse models of dementia, and reduction in affected region size, oxidative stress, and inflammation in mouse models of ischemic stroke following treatment with TwX.

Related StoriesNotably, the AOPP levels of mice treated with TwX were substantially lower than that of the healthy animals. Moreover, TwX treatment significantly reduced skin thickness, accumulation of the collagen protein, skin levels of hydroxyproline-;an oxidative stress marker, and fibrosis of the skin and lungs.

Sclerosis Autoimmune Disease Autoimmunity Blood Blood Vessels Dementia Fibrosis Genetic Immune System Inflammation Life Science Medical Research Mouse Model Oxidative Stress Protein Research Skin Stress

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