The compositional and functional diversity of the gut fungal microbiome

By Bhavana KunkalikarSep 30 2022Reviewed by Danielle Ellis, B.Sc. In a recent study published in The Lancet Microbe, researchers assessed the role of gut bacterial microbiome assembly and the gut mycobiome in relation to health, pathology, and clinical applications.

Furthermore, alterations in the gut mycobiome have also been causally or associatively linked to the onset and development of cancers like colorectal and pancreatic ductal adenocarcinomas. A relationship has also been found between mycobiome alterations and the emergence of intestinal graft-versus-host disease following allogeneic hematopoietic cell transplantation.

Disrupted association between gut fungi and bacteria in disease To track the evolution of the gut microbiome ecology, a 2021 study collected the longitudinal absolute abundances of fungal and bacterial species in the gut of preterm infants. An inverse correlation between bacterial and fungal loads in the guts of preterm infants was observed, and a single fungal species hindered several dominant genera of gut bacteria during infant development.

Additionally, it has been found that both healthy people and people with inflammatory bowel disease have antibodies against fungal beta-glucan and other fungal antigens in their serum, indicating that fungi may also trigger host humoral response.

Source: Healthcare Press (healthcarepress.net)

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