The complex relationship between obesity and male reproductive function

By Dr. Sanchari Sinha Dutta, Ph.D.Apr 9 2024Reviewed by Lily Ramsey, LLM In a review article published in the journal Molecular Aspects of Medicine , authors have analyzed current evidence on the impact of obesity on the male reproduction system.

Impact of obesity on male infertility A body mass index of 30kg/m2 or more is defined as obesity. The body fat percentages of more than 25% in men and 30% in women are also described as obesity, which are often poorly correlated with BMI in the context of obesity diagnosis. One most recent meta-analysis, including studies following the 2010 WHO manual for sperm parameter analysis, has shown that obesity can significantly reduce total sperm count, sperm concentration, and sperm progressive, and total motility.

Mechanisms involved in obesity-related male infertility One of the potential factors responsible for hypogonadism is excess visceral fat deposition. Hypogonadism is associated with excessive conversion of testosterone into 17ß-estradiol by adipocytes, which further promotes the secretion of sex hormone-binding globulin by the liver.

Increased visceral fat can induce insulin resistance, reducing sex hormone-binding globulin secretion and subsequent induction in free estrogen levels. Free estrogen and inflammatory mediators produced due to insulin resistance can negatively affect the hypothalamic-pituitary-gonadal axis. Obesity-related chronic inflammation can also increase the production of free radicals, leading to sperm DNA damage and reduced sperm quality.

Blood Body Mass Index Cell Chronic DNA Estrogen Fertilization Glucose Glucose Metabolism Hormone Hypogonadism Infertility Inflammation Insulin Insulin Resistance Leptin Male Infertility Medicine Metabolism Prenatal Proliferation Reproduction Sperm Testosterone

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