The chicken and egg problem of fighting another flu pandemic

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Flu News

Pandemic,Antibodies,Antigen

Even a peep of news about a new flu pandemic is enough to set scientists clucking about eggs.

May 31 2024KFF Health News

It's not so funny, he said, when the currently stockpiled formulation against the H5N1 bird flu virus requires two shots and a whopping 90 micrograms of antigen, yet provides just middling immunity. "For the U.S. alone, it would take hens laying 900,000 eggs every single day for nine months," Bright said.The spread of an avian flu virus has decimated flocks of birds . Cattle in at least nine states and at least three people in the U.S.

The companies that make the cell-based influenza vaccines, CSL Seqirus and Sanofi, also have billions invested in egg-based production lines that they aren't eager to replace. And it's hard to blame them, said Nicole Lurie, HHS' assistant secretary for preparedness and response under President Barack Obama who is now an executive director of CEPI, the global epidemic-fighting nonprofit.

Pfizer and Moderna are testing seasonal influenza vaccines made with mRNA, and the government is soliciting bids for mRNA pandemic flu vaccines, said David Boucher, director of infectious disease preparedness at HHS' Administration for Strategic Preparedness and Response. But the vaccines currently in the national stockpile are not a perfect match for the strain in question. Even with two shots containing six times as much vaccine substance as typical flu shots, the stockpiled vaccines were only partly effective against strains of the virus that circulated when those vaccines were made, Adalja said.

Pandemic Antibodies Antigen Bird Flu Cell H5N1 Health And Human Services Immunity Influenza Manufacturing Public Health Research Technology Vaccine Virus

 

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