Wiltshire Police said the incident happened at about 16:00 BST on 1 October on the 55 Stagecoach bus from Calne to Swindon.
A man in his 50s from Croydon has been arrested on suspicion of sexual assault on a female and attempted sexual assault on a female."We would continue to urge any witnesses who were on the bus at the time to contact police, in particular, we would like to speak to a woman who approached the victim following the incident to check on her welfare," a police spokesperson added.
"We take reports of this nature extremely seriously and will fully investigate all reports of sexual assault within our community."
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