By Tarun Sai LomteMar 26 2024Reviewed by Lily Ramsey, LLM In a recent study published in eBioMedicine, researchers evaluated proteomic signatures in blood plasma and cervicovaginal fluid for endometrial cancer detection.
Conversely, cervico-vaginal fluid presents a promising alternative, leveraging the uterine cavity's connection to the lower genital tract to offer a less invasive biomarker source. About the study In the present study, researchers evaluated the performance of proteomic signatures from cervicovaginal fluid and plasma for endometrial cancer detection.
Related StoriesThe resultant spectral data were converted and searched against a human plasma library and a previously published library of 19,394 peptides and 2,425 proteins in the cervicovaginal fluid. Findings Overall, 118 postmenopausal females with symptoms were recruited. Of these, 53 had confirmed endometrial cancer, and 65 had no evidence of cancer. Most participants were White, and those with endometrial cancer were likely to be older and have a higher body mass index than controls.
The model with the top five discriminatory proteins had the least AIC value and was selected as a parsimonious model. PCA indicated a modest separation between cancers and controls. A three-plasma biomarker panel predicted endometrial cancer with AUC, sensitivity, and specificity of 0.87, 75%, and 84%, respectively.
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