Study shows obesity in childhood associated with more than double the risk of developing multiple sclerosis

Study shows obesity in childhood associated with more than double the risk of developing multiple sclerosisheld in Venice, Italy , shows that having obesity in childhood is associated with more than double the risk of later developing multiple sclerosis. The study is by Professor Claude Marcus and Associate Professor Emilia Hagman, Karolinska Institutet, Stockholm, Sweden, and colleagues.

Individuals were followed from obesity treatment initiation, or from 15 years of age if treatment was initiated earlier, until MS diagnosis, death, emigration, or August 2023, whichever came first. The authors used computer and statistical modeling to calculate any potential association. Due to previously reported genetic associations of MS, the authors also assessed levels of parental MS, which was present in 0.99% of the obesity cohort and 0.68% in the general population comparators.

The small number who have developed MS so far means that the study was not sufficiently statistically powered to state the increased risk of females developing MS—however, the results follow the generally increased risk to females . They add,"There are several studies showing that MS has increased over several decades, and obesity is believed to be one major driver for this increase. Thanks to our prospective study design, we can confirm this theory.

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