Reviewed by Danielle Ellis, B.Sc.Oct 24 2023 This discovery identifies a group of patients who may benefit from specialized, but yet-to-be determined treatments.
To investigate this errant immune response, Dr. Iliev and Dr. Takato Kusakabe, a postdoctoral fellow and a first author in the study, worked with numerous colleagues to acquire three large clinical cohorts of COVID-19 patients and develop a mouse model to study the disease. They collaborated with members of the Weill Department of Medicine and the Department of Pathology and Laboratory Medicine at Weill Cornell Medicine, including Dr. Stephen Josefowitz, Dr. Mirella Salvatore, Dr.
Related StoriesTurning to preclinical models, the investigators found that mice bearing fungi from patients with severe COVID-19 produced more neutrophils in their blood and lungs, and had signs of heightened inflammation when infected with SARS-CoV-2. However, giving them an antifungal drug reduced these effects.
Source: Healthcare Press (healthcarepress.net)
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