Study reveals key gut microbiome differences in prediabetic patients

By Dr. Priyom Bose, Ph.D.Apr 11 2024Reviewed by Benedette Cuffari, M.Sc. A recent Nutrients study compares the composition of the gut microbiome in prediabetic patients and healthy individuals.

For example, lifestyle changes, bariatric surgery, and medications are commonly used to prevent the progression of prediabetes to diabetes. Despite these interventions, a recent American Diabetes Association report indicated that most prediabetic patients eventually develop diabetes. Therefore, it is imperative to develop more effective interventions to prevent or reverse the prediabetic condition.

Considering these observations, it is important to understand the mechanism by which intestinal bacteria alterations influence the development of diabetes. This information could ultimately support the development of novel approaches to prevent the progression of prediabetes to diabetes. A total of 57 study participants were recruited from Taipei Tzu-Chi Hospital in Taiwan. Gut microbiota data of 60 healthy individuals between 18 and 65 years were obtained from biobanks and used as the reference group.

Gut microbiome profile of 117 fecal samples at the genus level. The remaining bacterial genera are summed as ‘Others’. Maintaining the integrity of intestinal mucosa can prevent the invasion of pathogenic bacteria in the blood and the destruction of pancreatic β-cells. This finding indicates the indirect role of Anaerostipes and Faecalibacterium in regulating blood glucose levels.

Prediabetes Bacteria Bariatric Surgery Blood Diabetes Diet Dysbiosis Fasting Glucose Glucose Metabolism Glycated Hemoglobin Healthcare Hemoglobin Insulin Insulin Resistance Metabolism Mortality Nutrients Surgery Type 2 Diabetes

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