May 30 2024IMIM An international study led by the Hospital del Mar Medical Research Institute, in collaboration with researchers from the Neuropsychopharmacology Group at the University of the Basque Country and researchers from the CIBER of Mental Health , and published in Nature Communications, may facilitate the creation of new personalized treatments for people diagnosed with schizophrenia.
High complexity study To reach these conclusions, the researchers conducted complex research. The starting point was to select various available molecules, although they are not approved drugs for humans, to analyze at a molecular level and through atomic-level simulations, their ability to interact with the type 2A serotonin receptor.
Moreover, in a mouse model designed to simulate schizophrenia symptoms, these compounds had specific behavioral effects depending on which G protein they activated. Thus, using pharmacological and genetic techniques in mice, it was found that one of these G proteins is involved in symptoms related to psychosis, and another type of G protein with cognitive deficits.
Source: Education Headlines (educationheadlines.net)
Drugs Hospital Language Medical Research Mental Health Neuropsychopharmacology Protein Psychosis Receptor Research Serotonin
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