By Tarun Sai LomteMay 29 2024Reviewed by Susha Cheriyedath, M.Sc. A recent study published in the journal Nature Neuroscience revealed that Plexin-B1, encoded by PLXNB1, regulates the activation of peri-plaque glial nets in Alzheimer’s disease .
Microglial phagocytic activity promotes plaque compaction, limiting the healthy neuron exposure to plaque. Furthermore, microglial coverage of plaques serves as a barrier limiting neurite exposure to neurotoxic protofibrillar Aβ hotspots. Amyloid plaques are also surrounded by reactive astrocytes. As such, the microglia and reactive astrocytes closely interact with Aβ and one another, forming peri-plaque glial nets.
A high density of Plxnb1 mRNA was observed in peri-plaque glial fibrillary acidic protein reactive astrocytes. Activated microglia around the plaque had scant Plxnb1 mRNA. Further, plexin-B1 expression was assessed using a Plxnb1 knockout allele containing a LacZ cassette before Plxnb1’s promoter and initial exons.
Related StoriesMoreover, plexin-B1 deletion reduced the number of peri-plaque microglia and the spacing of plaque-related microglia. Next, bulk RNA sequencing of the prefrontal cortex of mice with and without plexin-B1 was performed. This revealed over 2,700 genes with differential expression . Pathway analyses indicated that upregulated DEGs in mice without plexin-B1 were enriched for gene ontology terms associated with synaptic function and nervous system development.
Source: Healthcare Press (healthcarepress.net)
Glial Cell Allele Gene Genes Microglia Mouse Model Nervous System Neuron Neuroscience Pathology Protein RNA RNA Sequencing
We have summarized this news so that you can read it quickly. If you are interested in the news, you can read the full text here. Read more:
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Q&A: Researchers discusses 25-year study that shows mothers' empathy for teens may predict teens' empathyA new Child Development study from researchers at the University of Virginia provides the first long-term, longitudinal evidence for the transmission of empathic care across three generations: from mother to teen to child.
Source: medical_xpress - 🏆 101. / 51 Read more »
Researchers advocate for structured framework to study the benefits of exercise training in multiple sclerosis rehabA team of experts in multiple sclerosis (MS) research recommends a structured approach to the study of mechanisms of exercise training for improving outcomes for multiple sclerosis (MS).
Source: medical_xpress - 🏆 101. / 51 Read more »
Researchers study indicators of coronary obstructions in women with established coronary artery diseaseResearchers in medicine have been studying the composition of biochemical markers to determine correlations between during health and disease for several decades. The data helps health care professionals to accurately diagnose and treat diseases, some of which are life threatening.
Source: medical_xpress - 🏆 101. / 51 Read more »
Researchers develop 3D model to better treat neurological disordersA 3D model developed by West Virginia University neuroscientists shows how implantable stimulators—the kind used to treat chronic pain—can target neurons that control specific muscles to provide rehabilitation for people with neurological disorders such as stroke and spinal cord injuries.
Source: medical_xpress - 🏆 101. / 51 Read more »
Researchers discover compounds produced by gut bacteria that can treat inflammationResearchers at the University of Toronto have found naturally occurring compounds in the gut that can be harnessed to reduce inflammation and other symptoms of digestive issues. This can be achieved by binding the compounds to an important, but poorly understood, nuclear receptor.
Source: medical_xpress - 🏆 101. / 51 Read more »
Researchers target neurogenesis in new approach to treat Parkinson's diseaseResearchers at the University of Toronto have found a way to better control the preclinical generation of key neurons depleted in Parkinson's disease, pointing toward a new approach for a disease with no cure and few effective treatments.
Source: medical_xpress - 🏆 101. / 51 Read more »