Study explores how different modes of cell division evolved in close relatives of fungi and animals

May 23 2024European Molecular Biology Laboratory Yet, there is remarkable diversity in the way different organisms carry out this universal process. A new study from EMBL Heidelberg's Dey group and their collaborators, recently published in Nature, explores how different modes of cell division evolved in close relatives of fungi and animals, demonstrating, for the first time, the link between an organism's life cycle and the way their cells divide.

This question captured the attention of scientists in the Dey Group at EMBL Heidelberg, who investigate the evolutionary origins of the nucleus and cell division. Hiral Shah, an EIPOD fellow working across the three groups, led the study. "Having recognized very early that Ichthyosporea, with their many nuclei and key evolutionary position between animal and fungi, were well-suited for addressing this question, it was clear that this would require bringing together the cell biological and technical expertise of the Dey, Dudin, and Schwab groups, and this is exactly what the EIPOD fellowship allowed me to do," said Shah.

The study combined expertise in comparative phylogenetics, electron microscopy at EMBL Heidelberg), and ultrastructure expansion microscopy, a technique that involves embedding biological samples in a transparent gel and physically expanding it. Additionally, Eelco Tromer, from the University of Groningen in the Netherlands, and Iva Tolic, from the Ruđer Bošković Institute in Zagreb, Croatia, provided expertise in comparative genomics and mitotic spindle geometry and biophysics, respectively.

Cell Division Bacteria Electron Electron Microscopy Eukaryotes Evolution Fungi Genetic Membrane Microscopy Mitosis Nuclear Envelope Reproduction Research

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