By Dr. Chinta SidharthanDec 20 2022Reviewed by Aimee Molineux In a recent study published in PLOS ONE, researchers measured the seroprevalence against severe acute respiratory syndrome coronavirus 2 in blood donors from the states of Hesse, Lower Saxony, and North Rhine-Westphalia in Germany to determine the incidence of undetected asymptomatic SARS-CoV-2 infections.
About the study In the present study, the researchers used the remaining plasma samples from regular blood donors for anti-SARS-CoV-2 IgG antibody screening. Enzyme-linked immunosorbent assay was used for the initial detection of the viral spike protein. The seropositive samples were then subjected to chemiluminescent microparticle immunoassay to detect anti-receptor binding domain IgG antibodies. Anti-nucleocapsid antibodies were measured using a fully automated serological ELISA.
All the 88 samples that were analyzed for neutralizing antibodies and antibody avidity revealed a rapid decay of neutralizing and binding IgG antibodies against SARS-CoV-2 and low avidity during the 181 days of follow-up. When the results were analyzed according to sex, the IgG antibodies against SARS-CoV-2 were seen to decline more rapidly in males than females. Furthermore, neutralizing antibody persistence and increased avidity were stronger in female donors than in males.
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