Scientists create more efficient CAR immunotherapies using a molecular anchor

The molecular anchor concept is a new design for improving chimeric antigen receptor -based-immunotherapies. CARs have shown some promise in the clinic, but have yet to deliver widespread success across tumor types. The findings were published today in"We've come up with a new way to more efficiently and effectively bind and target cancer cells," said first and corresponding author Peter Chockley, Ph.D., St. Jude Department of Bone Marrow Transplantation and Cellular Therapy.

"Our approach is different because it focuses on organization," Chockley said."CAR structure, when it forms the immune synapse, is very disorganized. The anchoring domain we added organizes the internal scaffolding and makes a better signal, and then brings in other more natural adaptor signaling proteins. The simple addition of organization improves CARs dramatically."

Conventional CARs develop a disorganized immune synapse like a desk covered in a mess of cords, causing unclear signaling within the cells. By adding an anchoring domain to the bottom side of the CAR, the scientists organized the CARs—the molecular equivalent of adding cable ties to organize computer cables."The most attractive thing about this approach," said senior author Stephen Gottschalk, M.D., St.

United Kingdom Latest News, United Kingdom Headlines

Similar News:You can also read news stories similar to this one that we have collected from other news sources.

Horses and dogs sailed with Vikings to Britain, say scientistsA Viking leader probably chose his favourite animals to board a longboat to England, scientists say.
Source: bbcemt - 🏆 120. / 51 Read more »

Horses and dogs sailed with Vikings to Britain, say scientistsA Viking leader probably chose his favourite animals to board a longboat to England, scientists say. Slow news day? You've got time for this but you won't report on apartheid in Israel? How racist do you have to be to turn a blind eye to apartheid? The Vikings also brought flys to England.
Source: BBCNews - 🏆 3. / 97 Read more »

Scientists use AI algorithms to hunt for anti-cancer drugsSystem identified a candidate that appears more effective than FDA-approved drugs
Source: TheRegister - 🏆 67. / 61 Read more »