In this study, we are following up for a second time during the pandemic an adult population in Catalonia using multiplex antibody serology against SARS-CoV-2 in blood samples collected 6 months after the start of the vaccine rollout in Spain and incorporated questionnaire data and information from healthcare registries.
], the sub-region S2 , the nucleocapsid full length , and the specific NCt region produced at ISGlobal . In addition, 4 RBDs from different VoCs, produced at CRG , were used : Alpha , Beta , Gamma , and Delta .
ISGLOBALorg BMCMedicine 100% of people that never got Covid and were never vaccinated still don’t care.
physorg_com ISGLOBALorg BMCMedicine Still a longer period compared to vaccines and no myocarditis risk involved.
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A living WHO guideline on drugs for covid-19Updates This is the twelfth version (eleventh update) of the living guideline, replacing earlier versions (available as data supplements). New recommendations will be published as updates to this guideline. Clinical question What is the role of drugs in the treatment of patients with covid-19? Context The evidence base for therapeutics for covid-19 is evolving with numerous randomised controlled trials (RCTs) recently completed and under way. The emerging SARS-CoV-2 variants (such as omicron) and subvariants are also changing the role of therapeutics. This update provides updated recommendations for remdesivir, addresses the use of combination therapy with corticosteroids, interleukin-6 (IL-6) receptor blockers, and janus kinase (JAK) inhibitors in patients with severe or critical covid-19, and modifies previous recommendations for the neutralising monoclonal antibodies sotrovimab and casirivimab-imdevimab in patients with non-severe covid-19. New or updated recommendations • Remdesivir: a conditional recommendation for its use in patients with severe covid-19; and a conditional recommendation against its use in patients with critical covid-19. • Concomitant use of IL-6 receptor blockers (tocilizumab or sarilumab) and the JAK inhibitor baricitinib: these drugs may now be combined, in addition to corticosteroids, in patients with severe or critical covid-19. • Sotrovimab and casirivimab-imdevimab: strong recommendations against their use in patients with covid-19, replacing the previous conditional recommendations for their use. Understanding the new recommendations When moving from new evidence to updated recommendations, the Guideline Development Group (GDG) considered a combination of evidence assessing relative benefits and harms, values and preferences, and feasibility issues. For remdesivir, new trial data were added to a previous subgroup analysis and provided sufficiently trustworthy evidence to demonstrate benefits in patients with severe covid-19, but not c
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