Researchers uncover how deadly MRSA pneumonia inhibits body's antimicrobial activity

By Vijay Kumar MalesuFeb 7 2024Reviewed by Danielle Ellis, B.Sc. In a recent study published in the American Journal of Physiology-Lung Cellular and Molecular Physiology, a group of researchers examined how heparan sulfate shedding impacts cathelicidin efficacy in Methicillin-Resistant Staphylococcus aureus pneumonia.

Further research is needed to fully understand the mechanisms by which HS shedding impacts AMP function, offering potential for novel therapeutic strategies in pneumonia treatment. The study employed surface plasmon resonance to examine the binding kinetics between AMP and HS, providing real-time, label-free interaction insights. Concurrently, bacterial growth curves were studied under various conditions to assess the effect of different heparin types on MRSA strains.

Study results In the present study, researchers utilized a murine model of MRSA pneumonia. Mass spectrometry analyses revealed a significant increase in HS in the airspace lining fluid of MRSA-infected mice compared to saline controls. Notably, this increase was characterized by a higher abundance of sulfated HS, particularly multi-sulfated disaccharides.

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