Researchers discover a 'training program' driving parietal cell development

May 10 2024Baylor College of Medicine Common conditions such as indigestion and heartburn as well as peptic ulcers, autoimmune gastritis and stomach and esophageal cancers have one thing in common – they involve disruptions of the normal activity of parietal cells in the stomach, the only cells in the body that produce acid. Despite their medical importance, little is known about the molecular and genetic pathways that direct the generation and maturation of PCs from stem cells .

Dr. Jason Mills, corresponding author, Herman Brown Endowed Professor of medicine – gastroenterology and co-director of the Texas Medical Center Digestive Disease Center at Baylor The researchers worked with a mouse model in which they eliminated existing PCs. "This triggered the production of new cells in which we were able to capture a first glimpse into the molecular and morphological steps involved when cells in the gastric epithelium commit to becoming PCs and then mature," Adkins-Threats said.

"Progenitor PC cells that were committed to expressing ERRγ, were destined to eventually become mature PCs," said Mills, a member of and co-associate director for cancer education at the Dan L Duncan Comprehensive Cancer Center. "Our findings indicate that ERRγ is responsible for regulating the differentiation and maturation of these acid secreting PCs."

Stomach Cancer Cell Food Gastritis Gene Genes Genetic Heartburn Indigestion Medicine Research

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