May 20 2024Mount Sinai Health System Using tiny fat particles loaded with genetic instructions to calm down inflammation, the treatment was shown to target problem-causing cells and reduce swelling and harmful molecules in mouse models of damaged skin.
Using lipid nanoparticles loaded with RNA encoding IL-4, a cell-to-cell signaling protein known as a cytokine, the therapy targeted dysfunctional macrophages while simultaneously reducing inflammation and "reactive oxygen species" in diabetic wounds. Yizhou Dong, PhD, corresponding author of the study, Professor of Immunology and Immunotherapy, and member of the Icahn Genomics Institute and the Marc and Jennifer Lipschultz Precision Immunology Institute at Icahn Mount Sinai
Related Stories"Our ultimate goal is to translate these findings into tangible benefits for diabetic patients. With further research and validation, this RNA-LNP therapy could potentially revolutionize diabetic wound management with one easily scalable application of a comparatively inexpensive therapeutic agent," says Dr. Dong.
Source: Education Headlines (educationheadlines.net)
Wound Healing Cell Cell Signaling Cytokine DNA Genetic Genomics Hospital Immunology Inflammation Medicine Nanoparticle Nanoparticles Oxidative Stress Oxygen Protein Research RNA Skin Stress Therapeutics
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