Primary pathophysiology of AD. The two primary lesions associated with AD are extracellular nonvascular aggregates of Aβ and intraneuronal protein inclusions secondary to aggregation of misfolded and abnormally phosphorylated protein τ . Credit: Radiological Society of North Americaexamines the use of monoclonal antibody therapies for treating Alzheimer's disease and alerts physicians to be on the lookout for a potential side effect: amyloid-related imaging abnormalities .
"FDA-approved drugs such as aducanumab, as well as upcoming newer-generation drugs, have provided an exciting new therapy focused on reducing the amyloid plaque burden in Alzheimer disease," said Amit K. Agarwal, M.B.B.S., M.D., lead author of the article and neuroradiologist at Mayo Clinic in Jacksonville, Florida.
following an inflammatory response, leading to the leakage of blood products and fluid into surrounding tissues. ARIA-E is the most common side effect of monoclonal antibody treatment. In two phase III trials, 35% of patients on the approved dose had ARIA-E. These trials also showed that most ARIA-E cases were clinically asymptomatic and that 98% were resolved at follow-up imaging. ARIA-E occurred most frequently between three and six months of treatment, with incidence sharply dropping after the first nine months.
We have summarized this news so that you can read it quickly. If you are interested in the news, you can read the full text here. Read more:
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Gene variant protects against Alzheimer's and Parkinson's diseasesAbout one in every five people carries a version of a gene that, although largely unsung, appears to confer protection against both Alzheimer's disease and Parkinson's disease, Stanford Medicine investigators and their colleagues have learned.
Source: NewsMedical - 🏆 19. / 71 Read more »
Discoveries on memory mechanisms could unlock new therapies for Alzheimer's and other brain diseasesScientists at the University of Colorado Anschutz Medical Campus have made a 'paradigm shifting' discovery on the mechanisms required for learning and memory that could lead to new therapies for Alzheimer's disease and potentially Down syndrome. The study was published in the journal Nature.
Source: medical_xpress - 🏆 101. / 51 Read more »
New blood test gives high accuracy screen for Alzheimer's diseaseA new blood test called p-tau217 shows promise as an Alzheimer's disease biomarker, and when used in a two-step workflow very high accuracy to either identify or exclude brain amyloidosis, the most important and earliest pathology. That is an innovation now presented by researchers at the University of Gothenburg, together with colleagues at University of Lund and in Montreal, Canada.
Source: medical_xpress - 🏆 101. / 51 Read more »
New study finds genetic factor fends off Alzheimer's and Parkinson'sAbout one in every five people carries a version of a gene that—although largely unsung—appears to confer protection against both Alzheimer's disease and Parkinson's disease, Stanford Medicine investigators and their colleagues have learned. These lucky people may someday benefit all the more from a vaccine that could slow or stall the progression of these two most common neurodegenerative conditions.
Source: medical_xpress - 🏆 101. / 51 Read more »
Higher educational attainment may have a protective effect against Alzheimer's in people with genetic riskA new study by researchers from Mass General Brigham further illustrates that when it comes to risk of Alzheimer's disease, even genetically determined forms of the disease, genetics is only one piece of the puzzle.
Source: NewsMedical - 🏆 19. / 71 Read more »
Scientists reverse Alzheimer's plaque formation in animal models by boosting activity of key ion channelLosing the activity of a key ion channel in the brain may contribute to the buildup of a devastating and toxic protein responsible for the clumps of plaque that accumulate in Alzheimer's disease, a team of neurobiologists in China has found.
Source: medical_xpress - 🏆 101. / 51 Read more »