By Dr. Sanchari Sinha Dutta, Ph.D.Jun 28 2023Reviewed by Lily Ramsey, LLM A study published in the CDC journal Emerging Infectious Diseases describes the identification of a highly pathogenic avian influenza A virus in a domestic cat that lived near a duck farm infected by a closely related virus in France in December 2022.
The cat lived next to a duck farm, wherein a similar infection was detected in more than 8,000 ducks in December 2022. The cat initially experienced a deterioration in general health condition, including apathy and mild hyperthermia, followed by severe neurologic and respiratory symptoms. Phylogenetic analyses indicated that the cat-isolated virus belonged to the duck-isolated virus-like genotype. This viral genotype has predominantly circulated in France and Europe since September 2022.
Among 90 publicly available sequences of highly pathogenic avian influenza A clade 2.3.4.4b viruses detected in mammals, 20 had the E627K mutation, indicating a rapid selection of this mutation in mammalian hosts. Another reason could be increased surveillance of avian influenza in wildlife, leading to more detection of infection in mammals. In addition, a higher ability of currently circulating viruses to infect mammalian hosts might be responsible for the rise in mammalian cases.
Study significance The study described a case of highly pathogenic avian influenza A clade 2.3.4.4b infection in a domestic cat in December 2022. Sporadic infections by highly pathogenic avian influenza A clades one and 2.2 have been detected in cats since 2004.
Source: Healthcare Press (healthcarepress.net)
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