Proteomic biomarkers in blood plasma as predictors of dementia in healthy individuals

By Vijay Kumar MalesuFeb 13 2024Reviewed by Lily Ramsey, LLM In a recent study published in Nature Ageing, a group of researchers explored the predictive power of plasma proteomic profiles for future dementia onset in adults without dementia, utilizing a large cohort from the United Kingdom Biobank , focusing on key biomarkers for effective early detection and intervention strategies.

Recent proteomic efforts fall short due to small sample sizes and broad outcomes. Further research is needed to identify precise, reliable biomarkers for early dementia detection, enabling timely intervention and advancing prevention strategies. Blood samples were collected across the UK between 2007 and 2010, with the majority taken during the baseline visit. These samples were stored in ethylenediaminetetraacetic acid tubes, centrifuged to separate plasma, and then aliquoted and frozen at -80°C until analysis.

The study carefully tracked participants from their initial assessment until the earliest of either a dementia diagnosis, death, or the last follow-up in March 2023. Study results The study included 52,645 adults free of dementia at the outset, predominantly white with a slight female majority and a median age of 58.

Notably, Glial Fibrillary Acidic Protein and Neurofilament Light Chain emerged as highly significant predictors across dementia types, alongside Growth Differentiation Factor 15 and Latent Transforming Growth Factor Beta Binding Protein 2 .

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