Premenopausal oophorectomy reduces white matter integrity in the brain later in life

Atrium Health Wake Forest BaptistJun 20 2024 White matter refers to the nerve fibers that connect neurons in different areas of the brain.

We know that having both ovaries removed before natural menopause causes abrupt endocrine dysfunction, which increases the risk of cognitive impairment and dementia. But few neuroimaging studies have been conducted to better understand the underlying mechanisms." For the study, the research team examined data from the Mayo Clinic Study of Aging to identify women over the age of 50 with available diffusion tensor imaging, a magnetic resonance imaging technique that measures white matter in the brain. The cohort was comprised of:

Mielke said that 80% of participants who had their ovaries removed also had a history of estrogen replacement therapy. Therefore, the study was not able to determine whether the use of estrogen replacement therapy after PBO mitigated the effects of PBO on white matter integrity. She noted that the ovaries secrete hormones both before and after menopause .

Menopause Ovaries Dementia Epidemiology Estrogen Imaging Medicine Nerve Neurons Oophorectomy Ph Research Testosterone

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