Study: Rational Development of Hypervalent Glycan Shield-Binding Nanoparticles with Broad-Spectrum Inhibition against Fatal Viruses Including SARS-CoV-2 Variants. Image Credit: Kateryna Kon / Shutterstock
Molecularly-imprinted polymers , also known as plastic/artificial antibodies, are synthetic receptors with antibodies that mimic antibody binding through copolymerization in the presence of templates. Due to ease of preparation, storage stability, and cost efficiency, MIPs exhibit potential for different applications such as diagnosis, cancer therapy, virus recognition, and toxin neutralization. MIPs have been developed against viruses, but none with broad-spectrum activity.
The authors next studied the binding and kinetics of nanoMIPs to proteins with high-mannose glycans using biolayer interferometry. First, RNase B was used as the target protein, and the dissociation constant was 1.3 x 10-6 M, two-to-three orders of magnitude improved relative to the Kd of mannose. The Kd for SARS-CoV-2 S1 protein was 5.3 x 10-7 M. In contrast, NIPs did not bind to RNase or SARS-CoV-2 S1.
Potent inhibition of live viruses. a,b) The authentic SARS-CoV-2 virus RNA load at 3 days post-infection from Vero cells treated with different concentrations of nanoMIP. Mean ± SD, n = 3. c–f) Cytopathic effect images of Vero cells treated with nanoMIP , NIP , and MBL under the infection of live SARS-CoV-2 for 3 days.
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