. These discrepancies in reported inflammation may be related to the study populations or severity of COVID-19 infection. In an analysis of hospitalized patients with COVID-19 in the Mount Sinai Health System, cardiac injury was evident in 36% and was significantly associated with mortality. On the other hand, we did not observe differences in mean troponin levels at the index hospitalization, when comparing patients with vs. without COVID-19 infection.
There are some limitations in this study. First, clinical variables were extracted from the EHR and harmonized across four common data models, but are reflective of real-world practice and may be subject to residual heterogeneity. Second, the median post-discharge follow up time was approximately 1 year, and we were unable to consider longer-term sequelae. Third, we were unable to consider cardiac imaging and the majority of HF descriptions were nonspecific, e.g., “congestive heart failure”.
In conclusion, COVID-19 infection appears to be associated with an increased risk of incident HF. A suspicion of HF should be triggered in patients who experience respiratory or cardiac symptoms following recovery from COVID-19 hospitalization.The National COVID Cohort Collaborative represents a partnership between the Clinical and Translational Science Awards Program hubs , the National Center for Advancing Translational Science , the Center for Data to Health , and the community.
We conducted a secondary analysis of the “Level 2” deidentified N3C dataset, which redacted 17 personal identifiers and date-shifted longitudinal data to protect patient privacy. COVID-19 cases were included in our analysis if the first diagnosis date for COVID-19 occurred during inpatient hospitalization, inclusive of preadmission testing.
NatureComms SARSCoV2 primaryhealthcare The risk of heart failure after hospitalization with COVID-19 is reduced by prescribing sunlight, restoring gut microbiome health with probiotics and access to Mediterranean meals and improving nocturnal melatonin amplitude and volume. .
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