Polygenic risk score shows potential to predict survival outcomes in breast cancer patients

May 31 2024Roswell Park Comprehensive Cancer Center Arya Mariam Roy, MBBS, Hematology / Oncology Fellow at Roswell Park Comprehensive Cancer Center, will share the results of that study as the first and presenting author of "Breast cancer polygenic risk score and patient survival outcomes in the Pathways study" at the American Society of Clinical Oncology Annual Meeting in Chicago, May 31-June 4.

These include lower-penetrance gene variants, which individually may or may not lead to the disease. However, when several common, lower-penetrance gene variants are combined, they significantly increase the risk. A PGS is already a valuable tool for calculating the risk of developing breast cancer, and the current study indicates that it might be equally valuable for prognosis.

The Roswell Park study drew on the resulting data to compile four polygenic scores for each patient: PGS313 and PGS4k, PGS5k and PGS6m. Investigators then followed the participants to document their survival outcomes. By the end of the 2021 calendar year, the patients had been followed for a median of 10.5 years .

Related StoriesOf the four PGSs measured, only PGS313 was associated with the survival outcomes. Patients with medium and high PGS313 had a greater risk of recurrence, death from any cause, total breast cancer events and invasive disease compared with those who had low PGS313. Higher PGS313 was not associated with contralateral second primary breast cancer, breast cancer-specific death or any other second primary cancer.

Source: Healthcare Press (healthcarepress.net)

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