Oxford Covid vaccine's 90% effectiveness is down to LUCK after trials error

Oxford Covid vaccine's 90% effectiveness is down to LUCK after a mistake in trials

11/24/2020 2:32:00 PM

Oxford Covid vaccine's 90% effectiveness is down to LUCK after a mistake in trials

THE high effectiveness of the Oxford Covid vaccine is down to luck after a mistake in trials, its maker has admitted. Trial data found giving participants two full doses resulted in 62 per cent pro…

vaccines, which both revealed similarly promising results of around 95 per cent effectiveness last week.It has also been shown to work in different age groups, including the elderly, and there were no hospitalised or severe cases in anyone who received the jab.

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The preliminary data shows the vaccine works nine in ten times when it's first given as a half dose, then followed by a full dose a month later.It’s not clear why, but the team think it could be that a smaller dose may be a better way of kicking the immune system into action.

The effectiveness drops to 62 per cent when given as two full doses at least one month apart, to give a combined average efficacy of 70 per cent - which experts say is more than most flu jabs.Health Secretary Matt Hancock said that the Medicines and Healthcare products Regulatory Agency (MHRA) would now assess if the 90 per cent effectiveness dosing regime could be used. headtopics.com

He told BBC Breakfast: "I'm really very pleased, I really welcome these figures - this data that shows that the vaccine in the right dosage can be up to 90 per cent effective.6The UK has ordered 100 million doses of the jab - with four million expected to be ready before the end of the year

Credit: PA:Press AssociationThe Oxford Covid jabs could be ready to roll out as early as next monthCredit: AP:Associated Press"Of course, it's vital that the independent regulator, the MHRA, will need to look at the data, will need to check to make sure that it's effective and safe of course.

"But we've got 100 million doses on order and, should all that go well, the bulk of the rollout will be in the new year."Mr Hancock added that Brits could expect to see life return to normal by Easter next year.We've got 100 million doses on order and. should all that go well, the bulk of the rollout will be in the new year

Matt HancockHealth SecretaryPrime Minister Boris Johnson tweeted: "Incredibly exciting news the Oxford vaccine has proved so effective in trials. There are still further safety checks ahead, but these are fantastic results. Well done to our brilliant scientists at @UniofOxford & @AstraZeneca, and all who volunteered in the trials." headtopics.com

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The vaccine - called ChAdOx1 nCoV-19 - uses a harmless, weakened version of a common virus which causes a cold in chimpanzees.Unlike the Pfizer vaccine - which has been found to be 95 per cent effective - the Oxford jab can be stored at more standard fridge temperatures.

Prof Andrew Pollard, chief investigator of the Oxford trial, said: "These findings show that we have an effective vaccine that will save many lives."Excitingly, we've found that one of our dosing regimens may be around 90 per cent effective and, if this dosing regime is used, more people could be vaccinated with planned vaccine supply."

Prof Pollard told the BBC Radio 4 Today programme that it was important to begin mass vaccinations as soon as possible.Once we have protected the vulnerable in the population we will be able to start getting back to normalProfessor Andrew Pollardchief investigator of the Oxford Vaccine Trial

"The most important thing to get us back to normal is to use these vaccines - all of the vaccines that are going to be available - as soon as possible," he said."Once we have protected the vulnerable in the population we will be able to start getting back to normal." headtopics.com

"We have just got to get on with this as soon as possible."'STOP VIRUS IN ITS TRACKS'The results also revealed lower levels of asymptomatic infection in the smaller dose group, he said.Prof Pollard added: "There is just a hint in the data at the moment that those who got that regime with higher protection, there is a suggestion that it was also able to reduce asymptomatic infection.

"If that is right, we might be able to halt the virus in its tracks and stop transmitting between people."Speaking later a press briefing, he said not enough time has passed to know if people are still protected from the virus a year after being vaccinated.

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How does the Oxford/AstraZeneca vaccine work?The vaccine - called ChAdOx1 nCoV-19 - uses a harmless, weakened version of a common virus which causes a cold in chimpanzees.Researchers have already used this technology to produce vaccines against a number of pathogens including flu, Zika and Middle East Respiratory Syndrome (Mers).

The virus is genetically modified so that it is impossible for it to grow in humans.Scientists have transferred the genetic instructions for coronavirus's specific "spike protein" - which it needs to invade cells - to the vaccine.When the vaccine enters cells inside the body, it uses this genetic code to produce the surface spike protein of the coronavirus.

This induces an immune response, priming the immune system to attack coronavirus if it infects the body.It differs from the Pfizer and Moderna vaccines because they use messenger RNA technology (mRNA).Conventional vaccines are produced using weakened forms of the virus, but mRNAs use only the virus's genetic code.

An mRNA vaccine is injected into the body where it enters cells and tells them to create antigens.These antigens are recognised by the immune system and prepare it to fight coronavirus.No actual virus is needed to create an mRNA vaccine. This means the rate at which the vaccine can be produced is accelerated.

"We only started giving the second doses of vaccine in the UK in August," he told reporters."The increase in disease, as you know, started towards the end of September and so most of the cases have only relatively recently accumulated both in the UK and in Brazil.

"So that means we just have not had enough time yet to be able to say whether, a year later, people are still as protected as they were at the beginning. So I think this is a 'watch this space' question."SCALING UP PRODUCTIONThe UK has placed orders for 100 million doses of the Oxford vaccine - enough to vaccinate most of the population - with rollout expected in the coming weeks if the jab is approved.

It also has orders for 40 million doses of a jab from Pfizer and BioNTech, which has been shown to be 95 per cent effective.Another jab from Moderna, of which the UK has five million doses on order, is 95 per cent effective, according to trial data.AstraZeneca has said it will have enough of its candidate vaccine for 20 million doses in Britain by the end of the year - and 200 million globally.

Operations executive Pam Cheng told a briefing the company is also manufacturing enough "active" drug substance for 70 million doses for the UK by the end of March next year and 700 million globally.She said the company would keep the "active" drug substance in stock while it awaited regulatory approval around the world.

She said she expected that to translate into four million finished vaccine doses by the end of 2020, and 40 million finished doses by the end of Q1 next year.Britain's 350million vaccine dosesTHE government has ordered 350million doses of Covid-19 vaccine, with some ready to roll out by December 1.

This includes 40million doses of the promising Pfizer shot, which was revealed to be 90 per cent effect last week.These are the other vaccines which the government has pre-ordered:Oxford/AstraZeneca: 100million dosesA weakened virus that causes colds in chimpanzees, it has been shown to generate a strong immune response against Covid-19.

It has been genetically changed so that it is impossible for it to grow in humans, making it safe for children, the elderly and people with pre-existing conditions.Currently in phase-3 trials in the UK, USA, South Africa, Japan, Brazil and Kenya, more than 50,000 test patients have been given the vaccine. Early reviews have shown it to be safe.

A company in Australia has already started making millions of vials in the expectation that trials will be successful.Novavax: 60million dosesContains purified piece of the virus that causes Covid-19. When it is administered, the body recognises it as “foreign” and mounts a protective immune response.

It has been shown to generate more antibodies than in patients recovering from severe Covid-19 infections.Currently in phase-3 clinical trials in the UK and USA.GSK/Sanofi: 60million dosesUses the same protein as one of Sanofi’s seasonal flu vaccines coupled with a booster.

In phase-1 clinical trials but early results have been positive.Valneva: 60million dosesAn inactivated whole virus vaccine designed to prompt the body into creating high levels of Covid-19 antibodies.The government has invested in Valneva’s manufacturing facility in Livingston, Scotland, to create a major UK vaccine factory.

Currently in pre-trial research, with trials due to start in December.Pfizer/BioNTech: 40million dosesPrevents Covid-19 infection by targeting the virus’s “spike protein”, effectively disabling it before it can cause any damage.Tested on 40,000 patients, it is currently in phase-3 trials, but the first interim analysis has shown it is 90 per cent effective.

Janssen: 30million dosesUses a modified common cold virus to act like a Trojan horse that can deploy the Covid-19 virus’s “spike protein” to human cells, causing the body to generate antibodies.Phase-3 trials among 60,000 patients were recently halted temporarily after an unexplained illness in one volunteer. Trials have since resumed.

=350million doses in totalThose calculations were based on using two full doses, she said, although trial data suggests higher efficacy when the initial shot is a half dose."If we go with a half dose you can imagine for the initial dose, we will be able to double the number of vaccinations here," she said.

She said the figures referred to the vaccine doses being manufactured by AstraZeneca, and not those being made by manufacturing partners.TheFTSE 100 edged up this morningrising almost one per cent to 6,379 after the announcement was made.Pascal Soriot, chief executive officer at AstraZeneca, said the news is an "important milestone" in the fight against the pandemic.

He added: "This vaccine's efficacy and safety confirm that it will be highly effective against Covid-19 and will have an immediate impact on this public health emergency.The NHS's leaked vaccine roll-out scheduleEVERY adult will be vaccinated against Covid by April under radical NHS plans to bring an end to the pandemic, leaked documents reveal.

Leaked plans, seen by(HSJ), suggest health bosses are primed to immunise a record 44 million people within five months of a jab being available.Under draft proposals vaccination will start in early December, depending on regulatory approval.The ambitious provisional timetable sets out plans to protect the nation at breakneck speed – with five million jabs doled weekly:

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The sample is way way to small to judge its 90% 🤦‍♂️🤦‍♂️🤦‍♂️ how did that happen?...im so surprised🤡 Chance favors the prepared mind. Spare Uber Eats code: eats-uspt76 Get £15 off your first order of £15 or more. Enjoy!! 😋😋 😂😂😂 and they want people to trust the vaccine Sometimes that how these things happen. Is the Sun unhappy with the outcome or just stirring it as per usual.

⁉️ And that is the reason I don’t want it . All been rushed and incorrect information What an absolute nightmare of wording on your part, you make it seem like the effectiveness of the vaccine is down to luck which it isn’t. They just found the right doses by LUCK. Pure clickbait Before people criticise this too much, does it even matter how as long as the end game is reached? Many historical scientific discoveries were found by error and pure luck FFS! Penicillin for starters, then there’s the microwaves, x-rays, the pacemaker the list is endless.